Record signing Andy Carroll will continue his bid to regain full fitness in the last-16 second leg but may have to settle for a place on the substitutes' bench again.
The £35million January signing has made two recent substitute appearances since recovering from a thigh injury which had kept him out since December 28.
Liverpool will seek to overcome a 1-0 deficit from last week's match in Portugal without the services of captain Steven Gerrard, who has been sidelined for a month after a groin operation. Defender Daniel Agger may also only be fit for a place among the substitutes after missing the last three matches with a knee injury.
Midfielder Jonjo Shelvey is training again after knee surgery last month but is some way short of being ready for action, as are Martin Kelly and Fabio Aurelio (hamstring), while striker Luis Suarez is ineligible.
Liverpool (from): Reina, Carragher, Skrtel, Kyrgiakos, Johnson, Lucas, Spearing, Meireles, Rodriguez, Cole, Kuyt, Gulacsi, Wilson, Agger, Flanagan, Poulsen, Jovanovic, Carroll, Ngog, Pacheco.