Reading manager Brian McDermott will rest striker Shane Long for the Championship finale.
Long has had a brilliant season for the Royals - scoring 23 goals - but has drawn a blank in his last four appearances and will be given the day off with the club's place in the play-offs secured.
Winger Jimmy Kebe has missed the last three games with a thigh injury and will again miss out, though he is expected to be fit for the start of the play-offs.
Forwards Mathieu Manset and Simon Church will be given starting roles as McDermott looks to end the regular season with a win.
Goalkeeper Adam Federici returned to the side for the goalless draw at Coventry last weekend and is set to keep his place after fully recovering from the knee injury which put him out of action for nine games.
Derby manager Nigel Clough could give his side a youthful look for the match.
Ross Atkins may be handed his debut. The 21-year-old would become the fifth goalkeeper used by the Rams this season after Stephen Bywater, Frank Fielding, James Severn and Brad Jones.
Clough is also thinking about giving starts to midfielder Jeff Hendrick and forwards Conor Doyle and Callum Ball.
"The Reading game is a chance to start one or two of the youngsters," said Clough. "Ross, Jeff, Conor and Callum are all in with a shout for Saturday."
The match will see Robbie Savage make his final appearance for Derby as the veteran midfielder is set to retire at the end of the season.