Scunthorpe boss Alan Knill could be without striker Chris Dagnall.
The former Rochdale forward picked up a knock to his hip in last week's 5-1 defeat at Nottingham Forest and is unlikely to recover.
He joins Josh Wright (back), Andy Hughes (stomach strain) and Matt Godden (groin) on the treatment table.
Defender Cliff Byrne and midfielder Garry Thompson remain long-term absentees but Knill has no other major concerns.
Knill said: "Cliff has done some light training, but Garry only had his operation the other week.
"It will be a long way back for them both. But now with a month or so off they have the time to get themselves right for the start of next season."
Dave Kitson is pushing to return for Portsmouth.
The striker has missed the last two matches with a rib injury but is being considered for a place in the squad.
Midfielder Liam Lawrence returned from a leg injury as a substitute during the 1-0 defeat by Norwich on Monday night.
He could be handed a start in place of full-back Carl Dickinson, who deputised in midfield against the Canaries.
Ritchie de Laet, Joel Ward (both calf) and Hermann Hreidarsson (knee) have been playing on despite carrying knocks recently and should continue.
Defender Ricardo Rocha is still suspended for Pompey, who are limping towards the finish line without a win in their last seven outings.