Sir Alex Ferguson must decide whether to recall Nani following his two assists against Fulham at the weekend.
The Portugal winger only made the bench at Stamford Bridge last week but
Javier Hernandez could make way from the team that started that game.
Rafael is doubtful with a knee injury with John O'Shea the automatic replacement if the Brazilian fails to make it.
Jose Bosingwa is back in contention for Chelsea.
The Portuguese right-back missed the 1-0 Premier League home win over Wigan on Saturday due to illness.
Alex is also included in Chelsea's travelling party after making his return from knee surgery off the bench at the weekend.
Brazilian defender David Luiz is cup-tied having played for Benfica earlier in the competition.
Manchester United (from): Van der Sar, Kuszczak, Rafael, O'Shea, Brown, Ferdinand, Smalling, Evans, Vidic, Evra, Fabio, Valencia, Gibson, Anderson, Scholes, Park, Carrick, Giggs, Nani, Rooney, Berbatov, Hernandez, Owen.
Chelsea (from): Cech, Turnbull, Hilario, Ivanovic, Cole, Essien, Ramires, Lampard, Torres, Benayoun, Drogba, Mikel, Malouda, Bosingwa, Zhirkov, Ferreira, Kalou, Terry, Alex, Anelka.