Aaron Lennon has overcome his illness and is available for Tottenham, while
Steven Pienaar also appears to be fit after training with the squad on Tuesday morning despite his groin problem.
Vedran Corluka (ankle) and Niko Kranjcar (foot) are doubtful, however, while Jonathan Woodgate (calf), Alan Hutton (knee) and Peter Crouch (suspension) are all out.
Karim Benzema has been included in Real Madrid's 21-man squad.
The in-form France striker is back in contention after missing the 4-0 first-leg win with a hamstring injury, while Sami Khedira is also available after sitting out Saturday's 3-0 Primera Division win at Athletic Bilbao due to flu.
21-one-year-old centre-back Nacho Fernandez has been named in Jose Mourinho's squad, with Portugal defender Pepe suspended.
Lassana Diarra will play no part because of a hip problem and has stayed in Madrid along with fellow absentees Pedro Leon (knee) and Fernando Gago (groin).
Tottenham (from): Gomes, Cudicini, Pletikosa, Corluka, Assou Ekotto, Bassong, Gallas, Dawson, Kaboul, Lennon, Kranjcar, Pienaar, Huddlestone, Sandro, Modric, Jenas, Rose, Bale, Van der Vaart, Defoe, Pavlyuchenko.
Real Madrid (from): Casillas, Adan, Dudek, Carvalho, Ramos, Marcelo, Albiol, Arbeloa, Garay, Nacho Fernandez, Kaka, Granero, Alonso, Canales, Di Maria, Ozil, Khedira, Adebayor, Ronaldo, Higuain, Benzema.