Bolton manager Owen Coyle will make one enforced change as on-loan striker Daniel Sturridge is ineligible.
Rodrigo and Ivan Klasnic are among the contenders to replace Sturridge, who scored a brace in the victory against West Ham last weekend.
Midfielder Mark Davies is expected to be included in the squad after returning to training following an ankle problem.
Stuart Holden, Sean Davis and Sam Ricketts remain sidelined through injury.
Denmark goalkeeper Thomas Sorensen will be recalled by Stoke.
Manager Tony Pulis has opted to stick with Sorensen instead of Asmir Begovic as he has been a regular in previous rounds.
Striker John Carew could come into contention following a four-match absence with a back problem.
Stoke, who go into the clash on the back of a 3-2 defeat by Tottenham in the Premier League, will be captained by central defender Ryan Shawcross.
Bolton (from): Jaaskelainen, Robinson, Cahill, Wheater, Knight, Muamba, M Davies, Gardner, Petrov, K Davies, Elmander, Klasnic, Taylor, Alonso, Rodrigo, Cohen, Steinsson, Blake, Lee, Bogdan.
Stoke (from): Sorensen, Begovic, Huth, Wilson, Delap, Faye, Etherington, Whitehead, Jones, Collins, Fuller, Carew, Pugh, Whelan, Pennant, Wilkinson, Walters, Shawcross, Diao, Shotton.