Loan signing Stephen Ireland has been included in the Newcastle squad for the first time.
The 24-year-old could make his debut despite spending the last few days at the bedside of partner Jessica Lawlor after she suffered multiple injuries in a road accident last week.
Midfielder Cheick Tiote and defender James Perch return from suspension, but skipper Kevin Nolan completes his two-match ban. Goalkeeper Steve Harper has had an injection in his knee and is doubtful.
Wayne Rooney will return from suspension to spearhead Manchester United's attack.
Rooney is available after a two-match ban and is expected to replace Dimitar Berbatov.
Paul Scholes misses out following his red card at Wembley but fellow veteran Ryan Giggs is expected to return, whilst Jonny Evans returns from his own ban.
Newcastle (from): Harper, Krul, Sodeberg, Simpson, Ferguson, Enrique, Coloccini, Williamson, S Taylor, R Taylor, Perch, Tiote, Barton, Gutierrez, Guthrie, Ireland, Vuckic, Tavernier, Richardson, Lovenkrands, Ameobi, Ranger, Kuqi.
Man Utd (from): Van der Sar, Kuszczak, Rafael, O'Shea, Brown, Ferdinand, Smalling, Vidic, Evans, Evra, Fabio, Valencia, Gibson, Anderson, Park, Carrick, Giggs, Nani, Rooney, Berbatov, Hernandez, Owen.