Stoke will be without striker Ricardo Fuller, who suffered an Achilles injury after appearing as a substitute against Aston Villa on Saturday and was stretchered off.
The Potters will be hoping another striker in on-loan John Carew will be available to face Mick McCarthy's side.
The Norway international was ineligible to face his parent club Villa but was sidelined in any case through illness.
Wolves striker Sylvan Ebanks-Blake is a major doubt for the game.
He suffered a recurrence of a hamstring injury after appearing as a substitute during the weekend home draw with Fulham, after initially suffering the injury in the previous game against Everton when he came off at half-time.
Stephen Hunt, Steven Mouyokolo and David Jones will be added to the other 17 players on duty against the Cottagers.
Striker Kevin Doyle (medial ligament) misses out but full-back George Elokobi (hamstring) could return for the derby with West Brom on May 8.
Stoke (from): Begovic, Wilkinson, Huth, Shawcross, Wilson, Pennant, Whelan, Delap, Etherington, Jones, Walters, Sorensen, Whitehead, Diao, Collins, Faye, Pugh, Carew.
Wolves (from): Hennessey, Stearman, Craddock, Berra, Ward, Guedioura, Henry, Milijas, Jarvis, O'Hara, Fletcher, Mancienne, Kightly, Hahnemann, Vokes, Hammill, Foley, Hunt, Mouyokolo, Jones.