Mick McCarthy will give a late fitness test to striker Sylvan Ebanks-Blake ahead of the derby.
Ebanks-Blake has missed the last two games with the hamstring problem which flared up again during the 1-1 home draw with Fulham a fortnight ago.
Fellow forward Kevin Doyle has a slim chance of being involved after recovering from a knee ligament injury but it is more likely he will be saved for the final two games of the campaign.
Winger Michael Kightly (groin) is a major doubt while midfielder Dave Edwards will not be considered after having an injection to relieve his back problem.
West Brom will be without suspended midfielder Paul Scharner.
The former Wigan player serves a one-game ban after being sent off for the first time in domestic football in his career during last weekend's 2-1 home success over Aston Villa.
Baggies boss Roy Hodgson will check on the fitness of skipper Chris Brunt and defender Steven Reid before finalising his line-up. The duo missed the win over Villa with hamstring and calf injuries respectively.
Wolves (from): Hennessey, Hahnemann, Stearman, Craddock, Berra, Mancienne, Mouyokolo, Elokobi, Foley, Guedioura, Henry, Jones, Milijas, Jarvis, Hunt, Hammill, O'Hara, Kightly, Ebanks-Blake, Fletcher, Ward, Vokes, Doyle.
West Brom (from): Carson, Myhill, Reid, Hurst, Jara, Meite, Olsson, Pablo, Tamas, Shorey, Cech, Mulumbu, Brunt, Morrison, Cox, Vela, Tchoyi, Thomas, Barnes, Odemwingie, Miller, Fortune.