Wayne Rooney will return to the Manchester United side for Premier League title showdown.
Rooney has recovered from a minor hamstring strain while central defensive duo Nemanja Vidic and Rio Ferdinand are also set to be reinstated to the starting XI having been rested for Wednesday's Champions League win over Schalke.
Darren Fletcher will not start after his recent virus, with United needing to avoid defeat to retain top spot with two games remaining.
Chelsea manager Carlo Ancelotti has no injury concerns though Jose Bosingwa is out and and Yury Zhirkov is a doubt.
The Italian's biggest decision will therefore be whether to play both Didier Drogba and Fernando Torres up front.
Manchester United (from): Van der Sar, Kuszczak, Lindegaard, Rafael, O'Shea, Ferdinand, Vidic, Smalling, Evans, Brown, Evra, Valencia, Scholes, Anderson, Carrick, Fletcher, Gibson, Park, Giggs, Nani, Obertan, Rooney, Berbatov, Owen, Hernandez.
Chelsea (from): Cech, Ferreira, Terry, Luiz, Alex, Ivanovic, Zhirkov, Cole, Bertrand, Mikel, Essien, Ramires, Lampard, Benayoun, Kalou, Malouda, Anelka, Torres, Drogba, Turnbull.