Fernando Torres will start for Chelsea, manager Carlo Ancelotti has confirmed.
Torres was dropped for Sunday's defeat at Manchester United, which all but ended the champions' faint title hopes.
Jose Bosingwa will miss the final two matches of the campaign with a knee injury, while young full-back Ryan Bertrand (hamstring) will also sit out the Newcastle game.
Newcastle midfielder Cheick Tiote will not be risked to prevent him starting the new season with a suspension.
The Ivory Coast international is unlikely to figure in the final game against West Brom either after picking up his 14th booking last weekend, although manager Alan Pardew has admitted his is unlikely to use Alan Smith as a direct replacement following his return from a lengthy absence with an ankle ligament injury.
Kevin Nolan (ankle) and Steve Harper (knee) are both out after surgery this week and join Mike Williamson (broken arm), Hatem Ben Arfa (double leg fracture), Stephen Ireland and Leon Best (both ankle), Danny Guthrie (shin) and Dan Gosling (knee) on the sidelines. Youngsters Sammy Ameobi - the younger brother of Shola - Kazenga LuaLua and Greg McDermott are included in the squad.
Chelsea (from): Cech, Ferreira, Terry, Luiz, Alex, Ivanovic, Zhirkov, Cole, Zhirkov, Mikel, Essien, Ramires, Lampard, Benayoun, Kalou, Malouda, Anelka, Torres, Drogba, Turnbull.
Newcastle (from): Krul, Soderberg, Simpson, Ferguson, Enrique, Coloccini, S. Taylor, R. Taylor, Barton, Gutierrez, Vuckic, Tavernier, Richardson, Lovenkrands, Shola Ameobi, Ranger, Kuqi, LuaLua, McDermott, Donaldson, Sammy Ameobi.