St Mirren welcome John Potter and Michael Higdon back from suspension for the crucial encounter, which could secure St Mirren's SPL status.
Danny Lennon has a full squad for the visit of the Lanarkshire side.
David Elebert and Martin Canning are out for Hamilton.
Elebert has a hamstring injury while Canning has a stomach complaint.
Manager Billy Reid will also monitor Simon Mensing, who has a bruised rib.
St Mirren (from): Gallacher, McAusland, Travner, McGregor, Potter, Murray, Thomson, Higdon, Goodwin, Dargo, McLean, Van Zanten, Mair, Mooy, McGowan, Cregg, Barron, Samson.
Hamilton (from): Cerny, Kilday, Neil, McLaughlin, Mensing, Graham, Buchanan, McAlister, Hopkirk, Crawford, Chambers, Elliott, McDonald, Imrie, Hasselbaink, Murdoch, Carrington, Gillespie, Antoine-Curier.