Hamilton captain Alex Neil is suspended for the game.
The 29-year-old midfielder signed a new three-year deal with the Lanarkshire club on Thursday but will have to watch from the stand after being sent off against St Mirren last week.
Defender David Elebert is back after recovering from a hamstring and Conner McGlinchey, from the under-19s, will be added to the squad.
Ian Murray, Danny Galbraith and Michael Hart will miss out for Hibs and will be absent for the final three games of the season.
Galbraith returned from an ankle problem last week but will now be rested in order to recuperate for next season, while Murray and Hart will also be given extra time to rest, with the 2011/12 SPL season beginning on July 23.
Graham Stack (shoulder) and Matt Thornhill (knee) remain out.
Hamilton (from): Cerny, McLaughlin, Buchanan, Elebert, Elliott, McDonald, McAlister, Carrington, Antoine-Curier, McGlinchey, Crawford, Mensing, Imrie, Hasselbaink, Chambers, Murdoch, Hendrie, Gillespie, Kilday.
Hibs (from): Brown, Thicot, Dickoh, Hanlon, Booth, Miller, Palsson, Wotherspoon, Scott, Vaz Te, Sodje, Riordan, Nish, Stevenson, Stephens, Duffy, Divis, Trakys, McCann.