Mark McLaughlin is suspended for Hamilton.
The Accies defender was sent off in the defeat to St Johnstone at McDiarmid Park on Tuesday as Billy Reid's side lost their bid to avoid relegation.
Ziggy Gordon and David Hopkirk, who have been away on Scotland Under-19 duty in Denmark this week, are set to be added to the squad.
Inverness midfielder Russell Duncan returns to the squad.
Duncan was suspended for the SPL win over Hibernian.
Defender Chris Hogg remains on the sidelines with knee cartilage damage while Jonny Tuffey will continue in goal.
Accies (from): Cerny, Buchanan, Elebert, Neil, McDonald, Mensing, McAlister, Routledge, Gillespie, Crawford, Chambers, Neil, Imrie, Hasselbaink, Murdoch, Kilday, Elliott, Antoine-Curier, Gordon, Hopkirk.
Inverness (from): Tuffey, Innes, Munro, Gillet, Doran, Odhiambo, Tokely, Duff, Rooney, Polworth, Foran, Ross, Cox, Morrison, Sanchez, Sutherland, Esson, Duncan.