New signings Owain Tudur Jones, Chris Hogg and Thomas Piermayr could play for Inverness.
Hogg, who initially moved to Caley Thistle from Hibs in January, this afternoon rejoined the Highland club after failing to win a deal with Crewe and joins Jones and Piermayr in the squad.
Gregory Tade recovered from an Achilles problem to play in last week's 3-0 loss at Motherwell, while Aaron Doran is nearing a return to training and could be included, but Josh Meekings (ankle), Lee Cox (pelvis) and Billy McKay (ankle) are all out.
Sean O'Hanlon is poised to play through the pain barrier for Hibernian, but Martin Scott is out.
O'Hanlon suffered a broken toe in Tuesday night's friendly loss at Blackpool, yet may play, but midfielder Scott required six stitches to his knee and is out of the trip to Caley Thistle.
New signing Junior Agogo (thigh strain) is also set to miss out, while his fellow striker Akpo Sodje (knee) is doubtful after missing the Celtic and Blackpool matches. Sean Welsh (cheekbone) remains absent.
Inverness (from): Esson, Tokely, Shinnie, Ross, Foran, Sutherland, Proctor, Tuffey, Tansey, Doran, Aldred, Tade, Hayes, Gillet, Polworth, Morrison, Whyte, Jones, Piermayr, Hogg.
Hibernian (from): Stack, Wotherspoon, Hanlon, Stephens, Booth, Murray, Thornhill, Galbraith, Stevenson, Palsson, De Graaf, O'Hanlon, O'Connor, Sproule, Crawford, Horner, Taggart, Brown, Hart.