Danny Buijs and Paul Heffernan are in the Kilmarnock squad for the first time after recovering from injuries, while goalkeeper Anssi Jaakkola is also available again.
Danny Racchi (back) remains on the sidelines, while Gary Fisher is a doubt.
Ross Forbes is back in contention for Motherwell after serving a one-match ban in their victory over Inverness last weekend.
However, the midfielder is likely to have to settle for a place on the bench following an impressive display from his team-mates on the opening day.
Kilmarnock (from): Bell, McKeown, Clancy, Fowler, Ada, Kroca, Harkins, Silva, Dayton, Pascali, Kelly, Hutchinson, Hay, O'Leary, Gros, Buijs, Heffernan, Jaakkola.
Motherwell (from): Randolph, Hateley, Hammell, Craigan, Hutchinson, Jennings, Lasley, Law, Humphrey, Murphy, Higdon, Saunders, McHugh, Forbes, Smith, Lawless, Pollock, Hollis.