Will Hoskins should be in the Brighton squad for the first competitive match at the new Amex Stadium.
Striker Hoskins, a summer buy from Bristol Rovers, missed last weekend's friendly against Tottenham with a hip injury but was back in training on Thursday morning.
Hoskins will probably be on the bench with Ashley Barnes likely to get the nod to partner new £2.5million frontman Craig Mackail-Smith.
Player/assistant-manager Mauricio Taricco is also fit after a leg knock but fellow defenders Tommy Elphick (Achilles) and Adam El-Abd (foot) are still sidelined by injuries suffered at the end of last season.
Winger Will Buckley and full-back Romain Vincelot will hope to make their debuts while wideman Kazenga LuaLua starts after rejoining on loan from Newcastle.
Doncaster boss Sean O'Driscoll could hand a debut to several new signings when his side open their campaign.
Former Derby winger Giles Barnes this week penned a six-month deal following his release from West Bromwich Albion at the end of last season.
Barnes appeared in Rovers' final pre-season friendly at Grimsby last Friday.
He should be joined in the squad by fellow new recruits Tommy Spurr, Kyle Bennett, James Baxendale, Richard Naylor and Chris Brown.
Rovers also this week announced the signing of teenager defender Oscar Radford and Rachid Bouhenna.
However, a number of players remain sidelined through injury, including James O'Connor, James Chambers, Martin Woods, Brian Stock, Adam Lockwood, Shelton Martis and Mark Wilson.