St Mirren have lost Nigel Hasselbaink and Darren McGregor.
Hasselbaink is suspended for two games after a failed appeal against his red card at Tannadice while McGregor faces six to nine months out after damaging a cruciate ligament.
Paul McQuade returns from a hamstring strain but Hugh Murray, Aaron Mooy, Graeme Smith and David Barron are still missing.
Motherwell are without Steven Saunders and Keith Lasley.
Saunders is out for up to nine months after rupturing his Achilles on Scotland Under-21 duty while Lasley is suspended following his dismissal against Hearts.
But Shaun Hutchinson returns to replace Saunders in central defence after overcoming a head knock.
St Mirren (from): Samson, Van Zanten, Tesselaar, McAusland, Mair, Goodwin, McGowan, Teale, Thomson, Thompson, McQuade, McLean, McShane, McHugh, McKernon, Carey, Kennedy, McQuade.
Motherwell (from): Randolph, Hateley, Hammell, Craigan, Hutchinson, Jennings, Forbes, Law, Humphrey, Murphy, Higdon, McHugh, Smith, Lawless, Carswell, Page, Pollock, Hollis.