Sean Dyche continues to have an almost fully-fit squad as his Watford side welcome the Hammers.
Midfielder Stephen McGinn remains the only absentee as he continues his recovery from a long-standing knee injury.
Despite defeat, Dyche was able to take plenty of positives from Saturday's 1-0 home reverse to Derby and will not be tempted into many, if any, changes.
He kept faith with the same XI who started the opening weekend's 2-2 draw at Burnley, although Troy Deeney once again replaced Chris Iwelumo for the final 20 minutes and the former Walsall striker will be pushing for a start.
Summer signing David Mirfin came on for the final couple of minutes against the Rams to make his debut, while midfielder Prince Buaben is still waiting for his Hornets bow.
West Ham striker Carlton Cole could be in line to start his first match of the season.
The striker has come on as a substitute in the opening two games with boss Sam Allardyce saying he was short of match fitness.
But Cole put in a lively cameo in Saturday's 1-0 win at Doncaster and is pushing Frederic Piquionne for the lone striker's role.
Another forward, John Carew, has a week's training behind him after joining from Aston Villa and his fitness will be assessed along with George McCartney, who rejoined from Sunderland last week.
Winger Julien Faubert could be added to the squad after a hamstring injury but, Cole aside, Allardyce is set to stick with the side which secured their first win of the season at the weekend.