Hull winger Robbie Brady hopes to shake off a virus in time to start.
The Irish teenager has started in all three of the Tigers' league games since arriving at the KC Stadium on loan from Manchester United in July, but was forced out of the midweek defeat at Leeds due to the illness.
Midfielder Tom Crainey is expected to return to Nigel Pearson's squad after missing out in midweek due to a groin strain.
Strikers Dele Adebola and Aaron Mclean could return to the starting line-up after Pearson threatened to make changes after the 4-1 defeat at Leeds.
Defender Paul McShane (calf) and winger Cameron Stewart (knee ligaments) remain long-term absentees as the Tigers chase only their second win in their last 10 games on home soil.
Crystal Palace's injury problems are mounting ahead of the trip.
Kagisho Dikgacoi is facing a spell on the sidelines after injuring his hamstring against Coventry on Tuesday night, and fellow midfielder Owen Garvan is also likely to miss out with a hip problem.
Attacking midfielder Darren Ambrose missed out against the Sky Blues with a knee injury and remains doubtful along with striker Glenn Murray, who has been out for two games with an ankle knock.
Veteran frontman Steffen Iversen is still missing with hamstring trouble, Nathaniel Clyne is out with a foot injury and fellow full-back Dean Moxey serves the final game of a four-match ban.
Boss Dougie Freedman is close to signing ex-Hull defender Anthony Gardner and Mexican striker Antonio Pedroza but neither will be fit enough to figure.