Liverpool will be without midfielder Raul Meireles for the game.
Meireles suffered a collarbone injury in the Reds' Carling Cup second-round victory at Exeter on Wednesday and manager Kenny Dalglish expects him to be sidelined for a few weeks.
Dalglish will check on the condition of Glen Johnson (hamstring), while Steven Gerrard (groin) is still working his way back to fitness.
Marcos Alonso has become the latest Bolton defender to be hit by the club's injury jinx.
The former Real Madrid man faces eight to 12 weeks out after suffering a broken metatarsal in the Carling Cup victory over Macclesfield.
He joins Tyrone Mears (broken leg) and Sam Ricketts (Achilles) on the sidelines, although Gretar Steinsson (foot) could come into contention for the visit to Anfield.
Tuncay Sanli will hope to retain his starting role after scoring on his debut against Macclesfield in midweek, but Ricardo Gardner may miss out again as he struggles to overcome a groin problem.
Liverpool (from): Reina, Kelly, Carragher, Agger, Enrique, Adam, Lucas, Kuyt, Suarez, Downing, Carroll, Doni, Flanagan, Skrtel, Henderson, Spearing, Ngog, Robinson, Aurelio, Rodriguez, Cole, Wilson, Poulsen, Shelvey.
Bolton (from): Bogdan, Steinsson, Robinson, Cahill, Muamba, Eagles, Tuncay, Petrov, Gardner, Knight, Kevin Davies, Mark Davies, Klasnic, Reo-Coker, Blake, Pratley, Jaaskelainen, Davies, Wheater, Connolly, Blakeman.