Brighton skipper Gordon Greer should be fit for the visit of the Posh.
The centre-half was substituted during Tuesday's Carling Cup win over Sunderland with a tight calf but boss Gus Poyet expects him to be available.
However, full-back Romain Vincelot will miss out after suffering a shoulder injury against the Black Cats.
Forwards Will Buckley (hamstring) and Will Hoskins (hip) are close to returning but Poyet will not take any risks with them.
Defensive duo Tommy Elphick (Achilles) and Adam El-Abd (foot) are still recovering from the injuries they suffered at the end of last season but should be back next month.
Craig Mackail-Smith will lead the line against the club he left for £2.5million over the summer.
Darren Ferguson will pick from an unchanged squad for Peterborough.
However, it remains to be seen if the Posh boss will again name an unchanged starting XI.
Following the 7-1 thrashing of Ipswich, Ferguson fielded the same players against Middlesbrough in the Carling Cup on Wednesday night.
Striker Nicky Ajose was on the bench for the second-round defeat after recovering from a hamstring problem.
On-loan defender Ben Gordon and midfielder Ryan Tunnicliffe are among those players available to Ferguson should he wish to make changes.
Former striker Craig Mackail-Smith is likely to line up against Posh following his summer move from London Road to Albion.