Jason Shackell has been nursed through the week as Derby look to keep their stand-in skipper on the pitch for the visit of the Clarets.
Shackell battled through the final 15 minutes of the home victory over Doncaster last weekend despite his back stiffening up and causing him discomfort in a hamstring.
The defender was excused from training during the early part of this week.
Shackell and teenager Mark O'Brien are the Rams' only fit recognised centre-halves.
Striker Jamie Ward is also a doubt after limping out of the game against Doncaster after just 25 minutes because of a hamstring problem.
Derby are looking to equal their best start to a league season by winning five successive matches for the first time since 1905. That team kept three clean sheets in their first four games, something the present Rams side have also done.
Burnley boss Eddie Howe will assess the fitness of defender Michael Duff ahead of the game.
Duff was acting skipper during Tuesday's Carling Cup win over Barnet and was replaced at half-time by David Edgar after picking up a knock.
Midfielder Chris McCann is set for a return to the starting line-up after coming off the bench to score an extra-time winner in the 3-2 victory against Lawrie Sanchez's men.
Striker Danny Ings looks set to be sidelined until the new year after suffering a knee injury which requires a cartilage operation in training.
Fellow frontman Martin Paterson remains out of action with a troublesome thigh injury and midfielder Marvin Bartley serves the final game of a three-match ban.
