Arsenal are hopeful South Korea captain Park Chu-young will receive his visa to be available against the Swans.
The Gunners' other deadline-day signings - defenders Per Mertesacker and Andre Santos as well as midfield pair Yossi Benayoun and Mikel Arteta - are all expected to be involved.
Emmanuel Frimpong returns from suspension, but Carl Jenkinson must sit out after his red card in the 8-2 defeat at Manchester United, and Alex Song and Gervinho are still banned. Tomas Rosicky (knee) is sidelined along with Ryo Miyaichi (calf) while Jack Wilshere and Abou Diaby (both ankle) are longer-term absentees.
Swansea manager Brendan Rodgers will be without deadline-day signings Darnel Situ and Rafik Halliche for the game.
The south Wales club are waiting for international clearance from FIFA before they can field the duo, although fellow new signing Federico Bessone is available.
Defender Alan Tate is beginning his lengthy rehabilitation after breaking his leg in a golf buggy crash, while captain Garry Monk is once again absent with an ongoing foot injury. Craig Beattie is another absentee as the Swans go in search of a first win and goal of the season, the striker out with an ankle injury.
Arsenal (from): Szczesny, Sagna, Mertesacker, Koscielny, Gibbs, Arshavin, Ramsey, Frimpong, Arteta, Walcott, Van Persie, Fabianski, Santos, Park, Benayoun, Oxlade-Chamberlain, Chamakh, Miquel.
Swansea (from): Vorm, Williams, Taylor, Britton, Orlandi, Graham, Sinclair, Dyer, Dobbie, Routledge, Cotterill, Lita, Moore, Bessone, Moreira, Rangel, Agustien, Gower, Butler, Tremmel.