Bolton's trio of new signings David Ngog, Gael Kakuta and Dedryck Boyata are poised to make their debuts.
Stuart Holden has been playing for the Wanderers reserves as he continues his comeback from the knee injury he sustained in March, but is unlikely to feature at the weekend.
Ricardo Gardner (groin) is also still working his way back to full fitness, while Lee Chung-yong, Tyrone Mears (both broken leg), Marcos Alonso (broken metatarsal) and Sam Ricketts (Achilles) are long-term absentees.
Javier Hernandez is set to make his first start of the season for Manchester United.
Hernandez was sidelined after suffering concussion during United's pre-season tour of North America, however, with Danny Welbeck (hamstring) out, the Mexican is likely to get his chance.
Nemanja Vidic (calf) and Rafael (shoulder) are sidelined, with Ferguson expected to make few changes to the side that smashed eight goals past Arsenal on its last outing a fortnight ago.
Bolton (from): Bogdan, Steinsson, Robinson, Cahill, Muamba, Eagles, Tuncay, Petrov, Knight, Kevin Davies, Mark Davies, Klasnic, Reo Coker, Blake, Pratley, Jaaskelainen, Wheater, Boyata, Kakuta, Ngog.
Man Utd (from): De Gea, Lindegaard, Smalling, Ferdinand, Jones, Evra, Evans, Fabio, Nani, Park, Cleverley, Anderson, Carrick, Fletcher, Giggs, Young, Valencia, Rooney, Berbatov, Diouf, Owen, Macheda, Hernandez.