Loan signing Royston Drenthe could be pushing for his first Everton start after featuring for the reserves in midweek.
Fellow deadline-day arrival Denis Stracqualursi may also make his Toffees debut while Phil Neville is fighting to regain his place in the side after being left out last weekend.
With striker Louis Saha still not fully match fit Tim Cahill is expected to start in attack again.
Wigan defender Emmerson Boyce (hamstring) is rated only 50-50 for the game.
Defenders Steven Gohouri (calf) and Antolin Alcaraz (thigh) are getting closer to fitness but remain sidelined.
Manager Roberto Martinez, who made seven changes in the Carling Cup in midweek, will revert to a more familiar line-up but Shaun Maloney, David Jones and Patrick van Aanholt could make league debuts.
Everton (from): Howard, Hibbert, Neville, Distin, Jagielka, Baines, Barkley, Fellaini, Osman, Rodwell, Drenthe, Cahill, Stracqualursi, Mucha, Hibbert, Baxter, Bilyaletdinov, Vellios.
Wigan (from): Al Habsi, Caldwell, Figueroa, Lopez, Watson, Diame, Moses, Gomez, Rodallega, Di Santo, Jones, Stam, Van Aanholt, McArthur, McCarthy, Thomas, Sammon, Maloney, Crusat, McManaman, Kirkland.
