Andy Dawson will miss out for Hull after suffering a knee injury in training which could put him out for six weeks.
The Tigers captain has been sent for scans to determine the full extent of an injury suffered in an innocuous challenge.
The left-back will join Paul McShane and Cameron Stewart on the sidelines. Defender McShane (calf) misses out again while winger Stewart (knee ligaments) is a long-term absentee.
Manager Nigel Pearson made only one change as the Tigers beat Peterborough in their last match, with Martyn Waghorn making his debut and Matty Fryatt dropping to the bench.
Dawson could be the only one of that starting XI to miss out against Pompey, with Joe Dudgeon ready to slot in at left-back.
Portsmouth will be without their skipper Liam Lawrence.
The Republic of Ireland midfielder was sent off for two bookable offences during last weekend's 4-3 defeat at West Ham and serves a one-match ban.
Striker Dave Kitson should return to the squad, however, after missing out at Upton Park through illness.
Boss Steve Cotterill has no new injury worries, with defender Tal Ben Haim (back) and midfielder Hayden Mullins (groin) coming through unscathed last weekend following late fitness checks.
Hungarian forward Marko Futacs is pushing to make his full debut following his recent switch from Werder Bremen.
Pompey will head north still looking for their first away win of the season.