Wigan striker Hugo Rodallega will miss Saturday's visit of Tottenham and could be sidelined for a month after injuring his knee last weekend.
Defender Emmerson Boyce was absent for the defeat at Everton with a hamstring problem and remains a doubt.
Defenders Steven Gohouri (calf) and Antolin Alcaraz (thigh) are still not fully fit.
Spurs duo William Gallas and Aaron Lennon will miss the game due to respective calf and groin injuries.
Benoit Assou-Ekotto is doubtful due to a throat infection and Roman Pavlyuchenko and Niko Kranjcar will not travel to the north west because of hamstring injuries.
Danny Rose (ankle) and Steven Pienaar (groin) are back in training but are unlikely to be risked while Michael Dawson (Achilles) and Tom Huddlestone (ankle) are definitely out.
Wigan (from): Al Habsi, Caldwell, Figueroa, Lopez, Watson, Diame, Moses, Gomez, Di Santo, Jones, Stam, Van Aanholt, McArthur, McCarthy, Thomas, Sammon, Maloney, Crusat, McManaman, Kirkland.
Tottenham (from): Gomes, Friedel, Cudicini, Bale, Kaboul, Bassong, Corluka, Walker, King, Assou-Ekotto, Rose, Parker, Modric, Livermore, Townsend, Carroll, Falque, Sandro, Pienaar, Pavlyuchenko, Defoe, Dos Santos, Adebayor, Van der Vaart.