Goalkeeper Adam Legzdins will make his full debut for Derby in the game.
The summer signing from Burton made his first competitive appearance for the Rams as a second-minute substitute during the 2-1 victory over East Midlands rivals Nottingham Forest.
With England Under-21 international Frank Fielding suspended following his early red card at the City Ground, Legzdins is set to start.
Nathan Tyson made his long-awaited Rams debut as a second-half substitute against his former club last weekend after recovering from a groin injury and the forward could be involved again.
"He is well short fitness-wise, so we have got to be careful with him," said manager Nigel Clough. "We won't get carried away, all he has had is 20 minutes. But a good week's training this week and he will be there or thereabouts on Saturday."
Theo Robinson impressed in his first league start of the season against Forest and with leading scorer Steve Davies ready to return to the starting XI after being an unused substitute at the City Ground, Clough is spoilt for options up front.
Kevin Kilbane missed the Forest game with a hamstring injury he sustained in training last week. The left-sided player could be fit for Saturday but the visit of Barnsley on Tuesday night is a more likely return date.
Millwall have added Jay Simpson and Liam Feeney to their squad - the duo were cup-tied as the Lions were thumped 5-0 in the Carling Cup at Wolves on Tuesday night.
Midfielder Tamika Mkandawire was also missing at Molineux with a swollen knee and he too should be available, while goalkeeper David Forde, defender Paul Robinson and midfielder Liam Trotter are set to start after dropping to the bench.
Darius Henderson is still receiving treatment on a calf problem and is unlikely to figure while fellow striker Josh McQuoid is out with a virus.
Long-term absentees Therry Racon (ankle) and Shaun Batt (calf) are making progress but will not be ready by the weekend.