Frank Fielding will return in goal for Derby.
The England Under-21 international missed the 3-0 home win over Millwall as he served a one-match suspension following his red card in the victory at Nottingham Forest.
Summer signing Adam Legzdins made his first start for the Rams on Saturday and kept a clean sheet in what manager Nigel Clough described as an 'accomplished' full debut. However, Fielding will be restored to the starting XI against the Tykes.
"Adam's decisions on crosses were good and he came and punched a couple of balls and it was lovely for him to keep a clean sheet and everybody is delighted for him," said Clough. "But we have a number one in Frank and he will come back in.
"It was Adam's first start at this level and there were a couple of nervy moments, but that is to be expected. But it was a very competent and assured first start and next time we need him, he will be there and even better."
Stand-in skipper Jason Shackell is expected to face his former club despite the centre-half being forced off with a back problem late on against Millwall. Likewise, striker Jamie Ward suffered a cut around his eye at the weekend but he should also be fit.
Barnsley winger Matt Done rejoins a long list of injured players expected to miss the midweek clash.
The 23-year-old summer signing from Rochdale returned from a hamstring injury at Birmingham on Saturday, but aggravated the problem and was forced off in the 29th minute.
Teenager Jordan Clark replaced Done and may have impressed enough in his first appearance of the season to earn his full Barnsley debut.
Midfielder Miles Addison will be unable to feature against his parent club.
But boss Keith Hill will still be without strikers Danny Haynes (hamstring) and Craig Davies (groin), midfielders Reuben Noble-Lazarus (ankle) and Goran Lovre (knee), plus defenders Rob Edwards (hamstring) and Luke Potter (knee).
