West Ham have injury worries over Joey O'Brien and Matt Taylor ahead of the clash.
O'Brien is struggling with a tight hamstring and Taylor came off during Saturday's 1-0 win over Peterborough with a calf problem.
With Ivory Coast defender Guy Demel still doubtful with a hamstring injury, winger Julien Faubert could fill in for O'Brien at right-back.
That would give Tottenham loanee David Bentley a chance to make his full debut on the right wing, while Jack Collison is an option on the left if Taylor is ruled out.
Defender James Tomkins shrugged off a groin problem to appear as a late sub on Saturday, but winger Gary O'Neil is still missing with an ankle injury and striker Frederic Piquionne is suspended.
Jason Scotland is expected to shrug off a knock to be fit for Ipswich.
The striker was accidentally stamped on in what was an innocuous clash towards the end of Saturday's goalless draw at Middlesbrough, leading to his 85th-minute withdrawal.
Having received treatment on Saturday evening and Sunday, Scotland is set to be in contention at Upton Park.
Ibrahima Sonko started at the Riverside having made a speedy recovery from his knee ligament strain and the Senegalese centre-back should again feature.
Midfielder Mark Kennedy is likely to miss out once more, though, due to the setback in his recovery from a calf problem.
In any case, it is unlikely manager Paul Jewell will make any changes having seen his side pick up four points from their last two games, with the same XI set to start for the third match in succession.