Blackburn manager Steve Kean is still waiting on the fitness of defenders Scott Dann and Michel Salgado.
Neither player has trained this week and the pair will undergo late tests to determine whether they will be able to face City at Ewood Park.
Martin Olsson is definitely out through suspension following his red card at Newcastle but Gael Givet has recovered from the knock he sustained at St James' Park and should be available, while Kean confirmed Ryan Nelson and David Dunn are edging closer to a return.
Manchester City boss Roberto Mancini may give Edin Dzeko a starting role after the striker apologised for his angry reaction to being substituted against Bayern Munich in midweek.
With Carlos Tevez suspended by the club following his apparent refusal to come off the bench in Munich, the Bosnian is likely to partner Sergio Aguero in attack.
Nigel de Jong is vying to replace Gareth Barry in midfield and though Adam Johnson is back in training after an ankle injury it may be to soon for him.
Blackburn (from): Robinson, Samba, Dann, Salgado, Givet, Hoilett, Lowe, Nzonzi, Formica, Yakubu, Bunn, Hanley, Grella, Pedersen, Petrovic, Rochina, Goodwillie, Roberts, Vukcevic, Slew.
Manchester City (from): Hart, Pantilimon, Richards, Onuoha, Kompany, K Toure, Savic, Lescott, Clichy, Kolarov, Bridge, De Jong, Barry, Milner, Y Toure, Nasri, Aguero, Silva, Zabaleta, Dzeko, Johnson.