Defender Richard Stearman is Wolves' major new fitness doubt.
Stearman suffered a toe injury during the 2-1 defeat against Liverpool at Anfield and was substituted at half-time. If he is ruled out, 19-year-old Matt Doherty will start against the Magpies.
Striker Steven Fletcher has recovered from the groin problem which restricted him to a second-half substitute's role against the Reds. Jody Craddock, Ronald Zubar, Kevin Foley and Sylvan Ebanks-Blake are still unavailable through injury.
Davide Santon will be included in the Newcastle squad for the first time.
The 20-year-old Italian played 90 minutes for the reserves in midweek after having fluid drained from his knee and could make his senior debut at Molineux.
However, striker Shola Ameobi will miss out once again with a shoulder injury, while Alan Smith (hamstring) and Mike Williamson (broken arm) remain on the sidelines.
Wolves (from): Hennessey, Stearman, Johnson, Berra, Ward, Hunt, Henry, O'Hara, Jarvis, Edwards, Doyle, Doherty, Fletcher, Guedioura, De Vries, Elokobi, Hammill, Milijas.
Newcastle (from): Krul, Harper, Simpson, R. Taylor, Santon, Ferguson, Coloccini, S. Taylor, Tiote, Cabaye, Gutierrez, Marveaux, Obertan, Gosling, Guthrie, Ben Arfa, Abeid, Vuckic, Ba, Lovenkrands, Best, Sammy Ameobi.