Dean Hammond could be restored to the Southampton starting line-up.
The midfielder and Saints skipper was confined to the bench as the Championship leaders were beaten 2-1 at Cardiff on Wednesday night.
Left-back Dan Harding will be assessed having missed the last five matches with a knee injury, while long-term absentees Radhi Jaidi and Lee Barnard are also close to returning.
Veteran defender Jaidi has been out all season with a knee injury and striker Barnard has yet to appear due to an ankle problem, but both are back in training.
Centre-half Dan Seaborne is still out as he recovers from a head injury sustained during an assault outside a nightclub earlier this month.
Sean Dyche is likely to stick with a winning line-up when he takes his Watford side to the soauth coast.
Dyche made one change in midweek as out-of-form goalkeeper Scott Loach was dropped to the bench in favour of Rene Gilmartin, who made his first ever league start for the Hertfordshire club.
And despite going behind against Millwall at Vicarage Road, Watford hit back to prevail 2-1 late on.
Dyche has no major new injury problems to contend with ahead of the trip to St Mary's, where Saints are yet to drop any points so far this season.
Midfielder Piero Mingoia has joined defender Lee Hodson (both knee) on the sidelines, although the pair are unlikely to have made the matchday 16 in any case. Long-term absentee Stephen McGinn also continues to miss out with a knee problem of his own.