David Luiz could be rested as the Brazil defender only returned to the club on Thursday after playing a full 90 minutes twice for his country in the past week.
Fernando Torres serves the second instalment of his three-match ban, goalkeeping understudy Hilario is still recovering from a hip and back complaint, while Michael Essien (knee) is a long-term absentee.
Everton manager David Moyes will run the rule over a number of players ahead of the game.
Jack Rodwell should be available after his red card against Liverpool was rescinded, although the midfielder then sat out England Under-21s' match in Norway as a precaution and will have his condition assessed.
Moyes will also check on the fitness of Tim Cahill, who withdrew from the Australia squad during the international break, John Heitinga and Leon Osman, who all have unspecified injury problems.
Chelsea (from): Cech, Ivanovic, Bosingwa, Alex, Ferreira, Terry, Luiz, Cole, McEachran, Mikel, Romeu, Ramires, Lampard, Meireles, Mata, Malouda, Drogba, Anelka, Sturridge, Lukaku, Kalou, Turnbull.
Everton (from): Howard, Heitinga, Hibbert, Neville, Distin, Jagielka, Baines, Barkley, Fellaini, Osman, Rodwell, Drenthe, Cahill, Stracqualursi, Mucha, Bilyaletdinov, Vellios, Gueye, Saha, Coleman, Hahnemann.
Watch Chelsea v Everton live on ESPN and HD on Saturday.