Reading will be without Jay Tabb for the visit of the Rams.
Midfielder Tabb was taken to hospital during the weekend win at Burnley, after being knocked unconscious by a hefty clearance from Clarets keeper Lee Grant.
The 27-year-old was discharged in time to join his team-mates on the bus trip back to Berkshire, but he will not be allowed to take part in contact training for at least three days as he recovers from concussion.
Meanwhile, captain Jobi McAnuff is a doubt for the clash after picking up an ankle injury. The winger came off at half time at Turf Moor on Saturday, and could be replaced on the right by Noel Hunt.
However, manager Brian McDermott is hopeful Malian wide man Jimmy Kebe can finally shake off a leg injury in time for the fixture.
Kebe has not featured for the Royals since limping out of the 2-0 victory over Doncaster on September 17.
Derby have been dealt a double injury blow ahead of the trip to the Royals with Steven Davies and John Brayford set for spells on the sidelines.
Top scorer Davies faces around six weeks out after suffering a fracture just above the eyebrow during the 1-1 home draw against Southampton on Saturday.
Brayford missed the visit of the Championship leaders after sustaining a slight tear to a thigh muscle in training last week. The defender is expected to be unavailable for three weeks.
Centre-half Russell Anderson deputised for Brayford at right-back against Saints and is likely to do so again, unless manager Nigel Clough can bring in a loan signing in time for the trip to Berkshire.
With Davies out, Nathan Tyson could be about to make a timely return to contention. The summer signing from Nottingham Forest has only managed 24 minutes of first-team action as a substitute this season due to a groin injury.
Tyson is set to play in a behind-closed-doors friendly against Chesterfield on Wednesday so will not be involved against Reading. However, he could be included in the squad that travels to Middlesbrough at the weekend.