Adam Lallana could be available when table-topping Saints take on second-placed West Ham.
The attacking midfielder was ruled out of Saturday's 1-1 draw at Derby with a foot injury but boss Nigel Adkins is hopeful he will be passed fit.
Defender Frazer Richardson is a doubt after he limped off against the Rams.
Midfielder Jack Cork dropped into the back four at Pride Park but Danny Butterfield is a natural replacement at right-back and could earn a recall to the squad.
Centre-half Dan Seabourne is still recovering from head injuries sustained in an assault.
Veteran striker David Connolly, who spent a season with the Hammers eight years ago, will line up against his old club alongside 11-goal top scorer Rickie Lambert.
James Tomkins and Matt Taylor are injury doubts for the Hammers ahead of the game.
Centre-half Tomkins came off against Blackpool on Saturday with a groin problem and midfielder Taylor is still feeling a calf injury.
But fit-again full-back Joey O'Brien (hamstring) returns along with midfielder Henri Lansbury and striker Carlton Cole, who were rested at the weekend.
Robert Green (knee) is still out so Manuel Almunia keeps his place in goal, while wingers David Bentley (knee) and Gary O'Neil (ankle) are long-term absentees.
Boss Sam Allardyce must decide whether to stick with two up front after John Carew and Sam Baldock were both on target in Saturday's 4-0 win, or revert to a lone striker against the leaders.