Newcastle boss Alan Pardew has virtually a full squad to choose from for the game.
Skipper Fabricio Coloccini has had a minor toe problem, but is expected to be fit, while Haris Vuckic (broken hand) and Alan Smith (hamstring) are available again.
Only central defender Mike Williamson, who has recovered from surgery on an arm fracture, but is now battling an ankle injury, remains on the sidelines.
Hugo Rodallega is set for a return to the Wigan starting line-up after making his comeback from a knee injury as a substitute a week ago.
There could be changes elsewhere as Steve Gohouri had 45 minutes to forget out of position at left-back in the 3-1 defeat at home to Bolton.
That could signal a return for Maynor Figueroa, who was dropped to the bench at the weekend.
Newcastle (from): Krul, Elliot, Harper, Simpson, R. Taylor, Santon, Ferguson, Coloccini, S. Taylor, Tiote, Cabaye, Gutierrez, Marveaux, Obertan, Gosling, Guthrie, Ben Arfa, Abeid, Vuckic, Smith, Ba, Best, Shola Ameobi, Lovenkrands, Sammy Ameobi.
Wigan (from): Al Habsi, Boyce, Caldwell, Alcaraz, Figueroa, Watson, Diame, Moses, Gomez, McCarthy, Di Santo, Jones, Pollitt, Stam, Van Aanholt, McArthur, Lopez, Thomas, Sammon, Maloney, Crusat, Gohouri.