Boro midfielder Barry Robson will miss the clash through suspension.
The Scotland international will sit out the game after picking up his fifth booking of the season at Nottingham Forest on Tuesday evening.
Manager Tony Mowbray also has a series of injury doubts with central defensive duo Rhys Williams and Matthew Bates having missed the 2-0 defeat at the City Ground with groin and foot injuries respectively.
Both will be assessed ahead of the Rams' visit to Teesside, along with keeper Carl Ikeme and midfielder Kevin Thomson.
Ikeme was unavailable for the Forest game with a hand injury and Thomson suffered a hamstring strain, while Jonathan Franks is continuing his recovery from shoulder surgery.
Derby's injury problems show no signs of easing ahead of the trip.
Nathan Tyson was expected to be in the squad after being pencilled in for a reserve-team run-out on Wednesday. However, the forward's niggling groin problem flared up again causing him to miss the game.
With leading scorer Steven Davies already out for around six weeks with a skull fracture sustained last Saturday, Tyson is now not expected to be back until after the international break in mid-November.
John Brayford will not return until around the same time as he recovers from a slight thigh muscle tear, and manager Nigel Clough is trying to sign a right-back on loan in time for the trip to Teesside. Centre-half Russell Anderson filled in for Brayford during the draws against Southampton and Reading.
Left-sided player Kevin Kilbane featured for the reserves as he continues to regain fitness after a hamstring injury.
Teenager Callum Ball scored in the game as the Rams drew 1-1 with Chesterfield and he is expected to be in the squad again, while England Under-16 international Mason Bennett could also be part of the travelling party.