Sheffield Wednesday striker Ryan Lowe will return to contention.
Lowe, a summer signing from Bury, has made only two substitute appearances for the Owls due to an ankle problem, but could be included in Gary Megson's squad.
Megson has no new injury or suspension problems as his side look to extend their unbeaten league run to six matches.
Midfielder David Prutton returned as an unused substitute last week after missing the previous three games with a thigh strain and will be hoping to play some part.
Winger Jermaine Johnson is also pushing for a recall to the starting line-up after appearing after half-time in last week's Steel City draw, but defenders Jon Otsemobor (calf), Daniel Jones (ankle) and goalkeeper Nicky Weaver (knee) remain long-term absentees.
The Owls could go top of the table with victory if other results go their way.
Colchester boss John Ward is positive his side will travel to Sheffield in good shape.
Unbeaten in their last four matches, the U's will be without two centre-backs, suspended Magnus Okuonghae and Pat Baldwin who is nursing a broken toe.
Baldwin is likely to miss the next couple of matches, but Ward has been boosted by two new faces in training.
Matt Heath (ankle) and Tom Eastman have returned from injury and a loan spell respectively to help ease Ward's defensive woes.
Eastman has featured regularly for League Two high-fliers Crawley so far this season and the former Ipswich man is now in line to make his Colchester debut.