Yeovil manager Terry Skiverton has a number of players missing.
Assistant player-manager Nathan Jones and Frenchman Flavien Belson return from one-match suspensions as Luke Ayling begins a one-match suspension following his dismissal at Stevenage.
Dominic Blizzard made a surprise return in the draw at Broadhall Way, but at the expense of Steven MacLean who is now doubtful.
Paul Huntingdon (hand), Andy Williams (ankle), Gavin Williams and Jon Obika (both knee) are all still out and will not feature.
The Glovers slipped to the bottom of League One following the draw and have failed to win in seven games, but Skiverton believes his side can turn it round.
"We are going through a difficult spell but do I, as Yeovil manager, believe we will get out of this? 100 per cent and so do my players," he told BBC Somerset.
Leyton Orient will be without Charlie Daniels.
Left-back Daniels is starting a three-match ban after he was sent off for the first time in his career during Saturday's 1-1 draw against Sheffield United.
Boss Russell Slade, who managed Yeovil for almost three years, will check on Ben Chorley and Jimmy Smith.
If centre-half Chorley can shake off a thigh problem he could replace Daniels in a reshuffled back four, otherwise Elliot Omozusi or Mike Cestor will come in.
Midfielder Smith is also struggling with a thigh injury while goalkeepers Ben Alnwick (groin), David Button and Jamie Jones (both shoulder) and striker Jonathan Tehoue (broken wrist) remain in the treatment room.