Manchester City boss Roberto Mancini is set to revert to a full-strength line-up.
Mancini made 11 changes for the midweek Carling Cup win over the same opponents, giving the likes of Joe Hart, Vincent Kompany, Joleon Lescott, Yaya Toure, David Silva, Mario Balotelli and Sergio Aguero a night off.
Former England midfielder Owen Hargreaves is again ruled out with a minor calf problem while controversial striker Carlos Tevez is highly unlikely to be recalled.
Wolves boss Mick McCarthy is still without injured striker Steven Fletcher.
Fletcher has a calf problem, but he may be fit for the next game against Swansea.
Ronald Zubar (groin) is still not match fit, while Kevin Foley (ankle) is also out as Wolves look to respond to the 5-2 Carling Cup defeat they suffered to Mancini's side in midweek.
Manchester City (from): Hart, Richards, Kompany, Lescott, Clichy, Zabaleta, Kolarov, Savic, K Toure, Y Toure, Milner, Barry, Silva, Johnson, Nasri, De Jong, Aguero, Balotelli, Dzeko, Pantilimon.
Wolves (from): Hennessey, Elokobi, Stearman, Craddock, Henry, Ward, Hunt, Ikeme, Johnson, Berra, Jarvis, Vokes, Hammill, Milijas, O'Hara, Doyle, De Vries, Guedioura, Edwards, Ebanks-Blake.