West Brom will be without striker Shane Long.
The Republic of Ireland international will be sidelined for six weeks with the knee injury suffered during last weekend's clash with Aston Villa.
Somen Tchoyi and Simon Cox will be vying to partner Peter Odemwingie up front. Midfielders Paul Scharner and Graham Dorrans (both knee) and winger Jerome Thomas (foot) are expected to be fit.
Liverpool striker Luis Suarez is an injury doubt.
After scoring both goals in the Reds' 2-1 Carling Cup victory at Stoke on Wednesday night, Suarez limped off towards the end with an ankle problem and his condition will be assessed ahead of the game.
Manager Kenny Dalglish made eight changes for the tie at the Britannia Stadium and the likes of Steven Gerrard and Glen Johnson are set to return to the first XI.
The match will be televised live by ESPN, with coverage underway from 4.45pm.
West Brom (from): Foster, Fulop, Reid, Jones, Jara, Olsson, McAuley, Dawson, Tamas, Mattock, Shorey, Brunt, Morrison, Mulumbu, Scharner, Dorrans, Thomas, Gera, Tchoyi, Odemwingie, Cox, Fortune.
Liverpool (from): Reina, Kelly, Carragher, Skrtel, Agger, Enrique, Henderson, Gerrard, Adam, Downing, Lucas, Kuyt, Suarez, Doni, Johnson, Coates, Aurelio, Flanagan, Spearing, Rodriguez, Bellamy, Carroll, Robinson, Wilson.