Wigan boss Roberto Martinez is hopeful both leading scorer Franco Di Santo and midfielder James McCarthy will be able to play some part.
Both players missed last week's 1-0 defeat by Newcastle with hamstring problems but have trained this week with the rest of the squad.
Goalkeeper Chris Kirkland is recovering from a back problem after returning early from a loan spell with Doncaster.
Fulham defender Aaron Hughes will miss out at Wigan.
The 31-year-old has been ruled out for a couple of weeks with a thigh injury picked up during last week's 3-1 defeat to Everton and will therefore miss the trip to the DW Stadium.
Fellow defender Philippe Senderos will have a thigh injury of his own assessed on Friday, while Orlando Sa (hamstring) and Simon Davies (knee) are out.
Wigan (from): Al Habsi, Boyce, Caldwell, Alcaraz, Figueroa, Watson, Diame, Moses, Gomez, McCarthy, Di Santo, Jones, Pollitt, Stam, Van Aanholt, McArthur, Lopez, Thomas, Sammon, Maloney, Crusat, Gohouri, Rodallega, McCarthy.
Fulham (from): Schwarzer, Etheridge, Kelly, Riise, Hangeland, Baird, Senderos, Grygera, Briggs, Sidwell, Kasami, Murphy, Gecov, Duff, Etuhu, Dempsey, Johnson, Zamora, Dembele, Ruiz