Adam Lallana could be back in the Southampton squad.
Saints' star midfielder has missed the last four matches with a foot injury but has been training this week and boss Nigel Adkins says he is close to returning.
Skipper Dean Hammond is available after a one-match ban kept him out of Tuesday night's 2-0 Carling Cup defeat at Crystal Palace and defender Jose Fonte should return after a slight hamstring problem.
Adkins made 10 changes to his line-up in midweek and will recall his big-hitters against third-placed Boro.
Goalkeeper Kelvin Davies, defenders Frazer Richardson, Jos Hooiveld and Danny Fox, midfielder Guly do Prado and striker Rickie Lambert are all expected to be recalled.
Middlesbrough manager Tony Mowbray is expected to recall midfielder Barry Robson to his starting line-up.
Scotland international Robson missed last Saturday's 2-0 win over Derby due to a one-game ban.
Mowbray could hand Matthew Bates a late fitness test as the central defender struggles to overcome a foot injury.
Fellow centre-half Rhys Williams recovered from a groin strain to play the full 90 minutes against Derby and is expected to continue.
Goalkeeper Carl Ikeme has returned to Wolves for treatment on a finger injury and will not return to Boro as his loan deal was due to end on Tuesday, November 1, so Jason Steele should continue in goal. Both Kevin Thomson (hamstring) and Jonathan Franks (shoulder) remain sidelined.
Boro bounced back from their first league defeat of the campaign at Nottingham Forest with victory over Derby and could go level on points with leaders Southampton if they can become the first side to win at St Mary's Stadium this season.