Guly do Prado should be fit for Southampton.
The Brazilian forward scored twice in Saturday's win over Middlesbrough before coming off with a slight knee knock but manager Nigel Adkins expects to have an unchanged squad available.
Winger Adam Lallana came through 73 minutes unscathed after four games out with a foot injury and should be involved again.
Striker Lee Barnard is fit after his long-term ankle problem so defenders Radhi Jaidi (knee) and Dan Seaborne (head) are now the only injury absentees.
Saints are three points clear at the top of the table and will be looking to stretch their winning run at home to an amazing 17 league games.
Peterborough hope to have Craig Alcock back for the trip to the Championship leaders.
Alcock missed the 3-2 defeat to Watford on Saturday with the knock that forced him off against Leeds the previous weekend.
His absence saw Tom Kennedy make his first appearance since returning to Posh from a loan spell at Leicester. Ryan Tunnicliffe also made a rare start at Vicarage Road in place of Tommy Rowe while, as expected, Paul Taylor replaced suspended striker Lee Tomlin and partnered Emile Sinclair in attack. Tomlin will serve the second game of his three-match ban at St Mary's.
Manager Darren Ferguson has hinted at changes in midfield for the trip to the south coast.
"I don't think that anyone would argue against the fact that Mark Little, Gaby Zakuani and Craig Alcock have played well this season and Ryan Bennett has won an England Under-21 call-up so my back four and goalkeeper have been fine," Ferguson said.
"Our back five are playing okay, and that's not being critical of the rest of the team, but we must defend better as a team because it is killing us at the moment."