Skipper Nemanja Vidic returns for United as they look to record a fourth straight win since their derby-day annihilation when they entertain Sunderland.
Michael Owen (thigh) joins Ashley Young (toe), Ryan Giggs (hamstring), Chris Smalling (foot) and Tom Cleverley (ankle) on the sidelines.
United have not lost at home to the Black Cats since 1968, whilst Steve Bruce has never recorded a victory as a manager against his old club.
Sunderland boss Steve Bruce will make a late decision on midfielder David Vaughan ahead of the trip to United.
The 28-year-old is struggling with a groin injury, which could hand a chance to skipper Lee Cattermole to force his way back into the team.
Keeper Simon Mignolet is out for at least eight weeks with a fractured nose and eye socket - Trevor Carson has been recalled from his loan spell at Bury to provide back-up to Keiren Westwood - while John O'Shea (hamstring) will miss out against his former club.
Man United (from): De Gea, Lindegaard, Amos, Jones, Rafael, Fabio, Ferdinand, Evans, Vidic, Valencia, Anderson, Park, Fletcher, Gibson, Nani, Diouf, Hernandez, Rooney, Berbatov, Welbeck.
Sunderland (from): Westwood, Carson, Brown, Bardsley, Richardson, Turner, Laing, Cattermole, Gardner, Vaughan, Larsson, Colback, Elmohamady, Meyler, Sessegnon, Bendtner, Wickham, Ji, McClean, Cook.