Hull goalkeeper Peter Gulacsi could make his first appearance since August against the Hammers.
Current number one Adriano Basso was forced out of the midweek defeat at Barnsley due to tendonitis in his knee and is a major doubt for the weekend, so Gulacsi, on loan from Liverpool, could start his first game since the defeat at Leeds on August 16.
Manager Nigel Pearson has no other new injury or suspension worries, while injured trio Martyn Waghorn, Martin Pusic and Nick Barmby are battling to prove their fitness.
Striker Waghorn (hamstring), winger Pusic (groin) and player/coach Barmby (calf) have not been ruled out of playing some part and will be monitored.
Another winger, long-term absentee Cameron Stewart (knee ligaments), will not be included in Pearson's squad, but is closing in on his first appearance of the season after completing 40 minutes for the reserves this week.
The Tigers will be looking to bounce back after losing their first game in 10 at Barnsley on Tuesday night.
West Ham will be without Winston Reid when they head to Hull.
The New Zealand defender suffered a dislocated shoulder during the early stages of Tuesday night's goalless draw against Bristol City and will be out for at least a month, so Abdoulaye Faye will partner James Tomkins at centre-half.
Striker John Carew also looks set to miss out, having visited a specialist this week to assess a knee problem.
The duo join David Bentley, Henri Lansbury (both knee), Gary O'Neil (ankle), Matt Taylor (calf) and Guy Demel (hamstring) on the casualty list.
Midfielder Taylor and right-back Demel are on the mend but are more likely to be held back until after the international break.