Ipswich midfielder Lee Bowyer (back), centre-half Ibrahima Sonko (hamstring and tonsilitis) and fellow defender Damien Delaney (foot stress fracture) are all definitely missing.
Strikers Nathan Ellington and Daryl Murphy, who are both carrying muscle strains, are also doubtful and will be assessed ahead of kick-off.
One piece of good news is the return of defender Aaron Cresswell after a one-match ban.
Billy Sharp and El Hadji Diouf are set to continue in attack for Championship basement boys Doncaster at Ipswich.
Sharp confounded expectation to start Tuesday night's game with Middlesbrough just three days after the death of his two-day-old son.
The former Sheffield United forward opened the scoring with a magnificent volley and linked up well with debutant Diouf in an impressive opening half-hour before Rovers subsided to a 3-1 defeat.
Diouf made way for Giles Barnes in the closing stages and even though manager Dean Saunders admitted the former Liverpool, Bolton and Blackburn forward was only 70% fit afterwards, he is expected to start once more.
Ryan Mason suffered an ankle injury against Boro and is doubtful along with fellow midfielder Brian Stock (groin).
Chris Brown (knee) and Martin Woods (groin) are nearing fitness but the Portman Road clash is expected to come too soon for them, while John Oster will undergo an operation on a vertebrae problem next week and faces a lengthy spell on the sidelines.