Sheffield Wednesday's leading goalscorer Gary Madine will sit out the second game of his suspension.
Madine, who has scored 11 goals this season, had an initial one-match ban extended to two by the Football Association after admitting a charge of improper conduct following his dismissal at former club Carlisle last week.
Ryan Lowe, who has recovered from a long-term ankle problem, partnered Chris O'Grady up front in last weekend's win at Wycombe and the same two are expected to continue after impressing.
Manager Gary Megson is unlikely to make any other unforced changes, but Reda Johnson is doubtful with a groin injury and should he fail to prove his fitness, Mark Reynolds will step in at left-back.
Megson has no other new injury or suspension problems as his side look to keep pace with the top two.
Brentford will be without Karleigh Osborne for the trip.
Defender Osborne missed last Saturday's 2-1 win over Chesterfield with a foot injury and although a scan has showed the problem is not as serious as first feared, he will be out for at least a couple of weeks.
With fellow centre-half Leon Legge still missing with a hamstring injury, Watford loanee Dale Bennett keeps his place following a goalscoring debut last week.
Striker Gary Alexander could start after returning as a substitute against Chesterfield following two months out with a knee injury.
Midfielder Harry Forrester (hamstring) is still missing and boss Uwe Rosler is looking for a back-up goalkeeper on loan with Simon Moore (shoulder) out for a month.